山东大学研究生导师介绍-----马晨
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[个人简介]go to english version
姓 名马 晨
性 别男
出生日期1964-01
职 称教授(硕导)
研究类别有机化学
工作单位有机化学研究所
电 话13969081777
传 真0531-88564464
e-mailchenma@sdu.edu.cn
[学术简介]
b.sc. shandong university, china
m.sc. shandong university, china (advisor: prof. wen wang)
ph.d. changwon national university, s. korea (advisor: prof. dong-soo shin)
postdoc. hong kong university of science and technology, hong kong (prof. wei-min dai’s group)
visiting scholar, university of heidelberg, germany (prof. thomas j. j. mueller’s group)
[主讲课程]
medicinal chemistry, organic chemistry, organic experiment
[研究领域和兴趣]
synthesis of bioactive molecules and organic reaction methodology
our research focuses on three directions now: 1) synthesis of isoquinoline derivatives with multidrug resistance (mdr) modulating activity; 2) development of novel methodology for synthesis of [1.4]-oxazine derivatives; 3) synthesis of the natural product, such as bioactive flavone derivatives. the ongoing projects include:
i) design and synthesis of tetrahydropyridazino-[1,4]-oxazino-isoquinoline derivatives. the synthesized candidates shown multidrug resistance (mdr) modulating activity.
ii) the novel and facile synthesis of n-substitued pyridazino [1,4]-oxazinones via smiles rearrangement.
iii) general synthesis of carboxylic acids engineered on flavone scaffolds as specific ligands for pdz2.
[主要论著]
1. ma, c.; dai, w-m. et al. “general synthesis of carboxylic acids engineered on flavone scaffolds as specific ligands for pdz2”
in preparation.
2. ma, c.; wang, x.; dai, w-m. “microwave-assisted catalyst-free amination of aryl chlorides with amines”
in preparation.
3. ma, c.; liu, s-j.; xin, l.; falck, j. r.; shin, d-s. “novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction”
tetrahedron, 62, 9002-9009, 2006.
4. ma, c.; liu, s-j.; xin, l.; zhang, q.; ding, k.; falck, j. r.; shin, d-s. “synthesis and biological evaluation of pyridooxazine-tetrahydroisoquinoline derivatives as mdr modulators”
chem. lett. , 35, 1010-1011, 2006.
5. dai, w-m.; wang, x.; ma, c. “microwave-assisted one-pot regioselective synthesis of 2-alkyl-3,4-dihydro-3-oxo-2h-1,4-benzoxazines”
tetrahedron 61, 6879-6885, 2005.
6. ma, c.; cho, s-d.; falck, j. r.; shin, d-s. “synthetic study on tetrahydropyridazino-[1,4]-oxazino-isoquinoline derivatives with multi-drug resistance (mdr) modulating activity”
heterocycles 63: 1, 75-85, 2004.
7. ma, c.; cho, s-d.; falck, j.r.; shin,d-s. “the novel and facile one-pot synthesis of n-substitued pyridazino [1,4]-oxazines”
synth. commun. 34: 8, 1399-1405, 2004.
8. ma, c.; tan, y-b.; wang, l.; zhang, q-f. “total synthesis of (-)-praziquentel: an anthelmintic drug”
j. chem. res. (s) 3, 186-187, 2004.
9. cho, s-d.; park y-d.; kim, j-j.; lee, s-g.; ma, c. et al. “a one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones”
j. org. chem. 68, 7918-7920, 2003.
10. cho, s-d.; song, s-y.; hur, e-j.; ma, c.; joo, w-h.; falck, j. r.; yoon, y-j.; shin,d-s. “regioselectivity of pictet-spengler cyclization: synthesis of halotetrahydroisoquinoling”
tetrahedron lett. 42: 36, 6251-6253, 2001.
[科研项目]
[科研成果]
[所获专利]
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