山东大学研究生导师介绍-----赵宝祥
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[个人简介]go to english version
姓 名赵宝祥
性 别男
出生日期1959-09-23
职 称教授(硕导)
研究类别有机化学
工作单位有机化学研究所
电 话0531-88366425
传 真
e-mailbxzhao@sdu.edu.cn
[学术简介]
1978.10-1982.6 大连理工大学化学工程系学习（本科）
1983.9-1986.6 大连理工大学研究生院精细化工系学习（硕士研究生）
1986.7－1993.3 山东省化工研究院工作，工程师
1993.3－1998.3 日本名古屋大学，博士研究生，获得应用化学专业工学博士学位
1998.3－1999.9 山东大学化学院有机化学研究所，副教授
1999.10－2000.7 德国柏林工业大学有机化学研究所博士后研究员
2000.7－今 山东大学化学与化工学院有机化学研究所，教授
2003.7-2004.6 韩国昌原大学合成化学研究所博士后研究员
[主讲课程]
有机化学
有机化学实验
综合化学实验
有机合成新方法（研究生课程）
合成化学（研究生课程）
[研究领域和兴趣]
有机合成 药物化学，杂环化学,化学生物学
[主要论著]
1. fang wei, bao-xiang zhao, bin huang, lu zhang, chun-hui sun, wen-liang dong, dong-soo shin, jun-ying maio. design, synthesis and preliminary biological evaluation of novel ethyl 1-(2-hydroxy-3-aroxypropyl)-3-aryl-1h-pyrazole-5-carboxylate. bioorg. med. chem. letters 16, 2006, 16, 6342
2. pei-fu jiao, bao-xiang zhao*, wei-wei wang, qiu-xia he, mao-sheng wan, dong-soo shin, jun-ying miao. design, synthesis and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives. bioorg. med. chem. letters 16, 2006, 2862.
3.wei tan, bao-xiang zhao*, lei sha, pei-fu jiao, mao-sheng wan, lei su, and dong-soo shin microwave-assisted ring opening of epoxides in solvent free conditions synthetic communications 2006, 36, 1353.
4.tan, wei; zhao, bao-xiang*; shi, mei; sha, lei; miao, jun-ying; shin, dong-soo facile synthesis and evaluation of cell a549 growth inhibitory activity of 4-aryl-6-aryloxymethylmorpholin-3-one derivatives chin. j. chem., 2006, 24, 396.
5. sha, lei; zhao, bao-xiang*; fan, chuan-dong; tan, wei; li, xun; miao, jun-ying. synthesis and primary evaluation of lung cancer cell growth inhibitory activity of novel 3-arylmethyl-5-aroxymethylbutyrolactones. chin. j. org. chem. 2006, 26, 537.
6. zhao, bao-xiang*; schaudt, marco; blechert, siegfried. design and synthesis of potential macrocyclic zinc metalloprotease inhibitors. chin. j. chem., 2006, 1080
7. wan mao-sheng, zhao bao-xiang*, he qiu-xia, jiao pei-fu, wang da-wei, miao jun-ying. synthesis and bioactivity evaluation of ethyl 6-amino-2-substituted-1h-indole-3-carboxylates and their derivatives chin. j. org. chem. 2006, 1248.
8. le su, jing zhao, bao xiang zhao*, jun ying miao, de ling yin, shang li zhang, safrole oxide induced human umbilical vein vascular endothelial cell differentiation into neuron-like cells by depressing the reactive oxygen species level at the low concentration. bba - molecular cell research, 2006. 1763, 247.
9 jing zhao, junying miao, baoxiang zhao*, shangli zhang. suppressing the akt/nos signal pathway and activating fas protein in bfgf stimulated angiogenesis and vec growth by safrole oxide. the international journal of biochemistry and cell biology. 2006, 1603.
10. chuandong fan, weiwei wang, baoxiang zhao,* shangli zhanga, and junying miao. chloroquine inhibits cell growth and induces cell death in a549 lung cancer cells. bioorg. med. chem. 2006, 14, 3218.
11. du ay, zhao bx*, yin dl, zhang sl, miao jy. safrole oxide induces apoptosis by activating caspase-3, -8, and –9 in a549 human lung cancer cells. bioorg med. chem. lett. 2006, 16: 81-83.
12. du ay, zhao bx*, yin dl, zhang sl, miao jy. safrole oxide induces apoptosis by up-regulating fas and fasl instead of integrin β4 in a549 human lung cancer cells. bioorg. med. chem. 2006, 14, 2438-3445.
13. jing zhao, junying miao, baoxiang zhao, shangli zhang. upregulating of fas, integrin β4 and p53 and depressing of pc-plc activity and ros level in vec apoptosis by safrole oxide. febs letters, 2005, 579(25): 5809-5813.
14. jing zhao, bao-xiang zhao, junying miao, shangli zhang, deling yin . safrole oxide inhibits angiogenesis by inducing apoptosis. vascular pharmacology，2005，43(1)：69- 74.
15. du ay, zhao bx*, yin dl, zhang sl, miao jy. discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in a549 human lung cancer cells. bioorg. med. chem. 2005, 13: 4176- 4183.
16. tan, wei; zhao, bao-xiang*; sha, lei; jiao, pei-fu; wan, mao-sheng; su, lei alumina catalyzed synthesis of β-aminoalcohols from epoxides and aromatic amines. chin. j. org. chem. 2005, 25,1011-1014.
17. zuo hua, zhao bao-xiang, wang da-wei. progress in antidiabetic drugs. china new drugs 2005, 14(6) 672-678
18. sha, lei; zhao, bao-xiang;* tan, wei; jiao, pei-fu; wan, mao-sheng; su, lei. synthesis of novelα-ethoxycarbonyl-γ-butyrolactone derivatives. chinese journal of synthetic chemistry 2005, 13, 344-348.
19. jia hua-feng, wang kai-ming, zhao bao-xiang*. preparation of arylmethyl amine by hexamethylenetetramine. chinese journal of synthetic chemistry 2005, 13, 110
20. jing zhao, baoxiang zhao*, aiying du, qitao zhao, and junying miao. effects of novel safrole oxide derivatives, 1-propyl-3-(3,4-methylenedioxyphenyl) -2-propanol and isopropoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, on apoptosis induced by deprivation of survival factors in vascular endothelial cells，endothelium, 2004 ,11（5/6）267-273
21. aiying du, baoxiang zhao*, shangli zhang, junying miao*. safrole oxide induces apoptosis in a549 human lung cancer cells. experimental lung research 2004, 30：1－11.
22. wang da-wei; zhao bao-xiang*, wang kai-aming, zuo hua, sha lei, tan wei. synthesis of a now class of antifungal drug butenafine’s analogues. journal shandong university 2004, 39(5), 99-101.
23. zhao, bao-xiang*; sha, lei; tan, wei; zuo, hua; wang, da-wei synthesis of isochroman derivatives from 1-alkoxy (phenoxy)-3- (3,4-methylenedioxy) phenyl-2-propanol by oxa-pictet-spengler reaction. chin. j. org. chem. 2004, 24(10), 1300-1303.
24. sha, lei; zhao, bao-xiang*; tan, wei; miao, jun-ying. recent development of apoptosis inducer. chin. j. org. chem. 2004, 24（8） 864-871.
25. zuo hua, zhao bao-xiang*, tan wei, wang da-wei, sha lei. synthesis of 1,3-dihydroxyacetone derivatives. chin. j. org. chem. 2004, 24(3) 331.
26. tan wei, zuo hua, sha lei, wang da-wei, zhao bao-xiang* synthesis of 1-alkoxy-3-aroxy-2-propanol and 1,3-diaroxy-2-propanol. journal shandong university 2003, 38, 96.
27. tan wei, sha lei, zhao bao-xiang* application of epoxides in organic synthesis. chinese journal of synthetic chemistry 2003, 11(5), 384.
28. zhao bao-xiang; wang da-wei, zuo hua; qian guang-tao; miao jun-ying. synthesis of 1-alkoxy/phenoxy-3-(3,4-methylenedioxyphenyl)-2-propanol. chin. j. org. chem. 2003, 9, 1026.
29. zhao bao-xiang; du, ai-ying.; miao, jun.-ying.;et al. effects of novel safrole oxide derivatives, 1-methoxy-3-(3,4-methylenedioxyphenyl)-2-propanol and 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, on apoptosis induced by deprivation of survial factors in vascular endothelial cells. vascular pharmacology, 2003, 40, 183.
30. miao jun-ying, zhao bao-xiang, li hui-hui, zhang shang-li, du chun-qing. effect of safrole oxide on vascular endothelial cell growth and apoptosis induced by deprivation of fibroblast growth factor. acta pharmacol sin. 2002, 23 (4), 323-326.
31. zhao bao-xiang; siegfried blechert. design of a novel macrocyclic sulfonamide peptidomimetics and synthesis of the precursors. chemical journal of chinese universities, 2001, 22(12), 2045-2047
32. zhao bao-xiang. new method for forming c=c bonds in organic synthesis—atom economic ring-closing metathesis reactions. chinese journal of organic chemistry, 2001, 21(6), 445-452.
33. zhao bao-xiang. progress in the synthesis of isoquinoline-fused pyrroles. chinese journal of synthetic chemistry. 2001, 9(5), 397-402
34. zhao bao-xiang. application of nitrones in total synthesis of natural product. progress in chemistry 2000, 12(1), 77-88.
35. zhao bao-xiang, shoji eguchi. 1,3-dipolar cycloaddition reaction of 6,7-dimethoxy-3,4-dihydroisoquinoline n-oxide with diketene: a novel consecutive rearrangement to hexahydropyrrolo[2,1-a]isoquinolines. heterocyclic commun. 1998, 4(2), 113-123.
36. zhao bao-xiang; shoji eguchi. 1,3-dipolar cycloaddition reactions of substituted 3,4-dihydroisoquinoline n-oxides with allenes. tetrahedron, 1997, 53 (28), 9575-9584.
37. zhao bao-xiang; shoji eguchi. synthesis of 5,6-dihydropyrrolo [2,1-a]- isoquinolines by rearrangement of 5-methylene- isoxazolidines generated from 1,3-dipolar cycloaddition of 3,4-dihydroisoquinoline n-oxide with allenes: a novel consecutive rearrangement to fused-ring pyrrole derivatives. j. chem. soc., perkin trans. 1, 1997, (20), 2973-2977.
38. zhao bao-xiang; yang yu; shoji eguchi. synthesis of nitrones from 3,4-dihydroisoquinoline derivatives by oxidation with m-chloroperoxybenzoic acid. org. prep. proc., int., 1997, 29(2), 185-194.
39. zhao bao-xiang; yang yu; shoji eguchi. synthesis of stable d4-isoxazolines by 1,3-dipolar cycloaddition of 3,4-dihydroisoquinoline n-oxides with alkynes and their rearrangement to isoquinoline-fused pyrroles. tetrahedron, 1996, 52 (37), 12049-12060.
40. zhao bao-xiang; shoji eguchi. novel synthesis method of 3,4- isoquinoline-fused pyrroles via 1,3-dipolar cycloaddition. the nagoya coe conference 1997
[科研项目]
1. 教育部留学回国人员科研启动基金（1999－）
2. 山东大学杰出青年科研基金（1999－）
3. 山东大学跨学科预研基金（2002－）
4. 山东省自然科学基金重点项目（第二负责人）（2003－2005）
5. 教育部重点项目（2004－2006）
6. 山东省自然科学基金项目（2006－2008）
[科研成果]
[所获专利]
两项授权发明专利, 四项发明专利正在申请。
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